ERBB2 S653C

CI-VAR-00004091Explore in graph →NP_004439.2:p.Ser653CysNM_004448.4:c.1958C>GCIViC 4541

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Bladder Urothelial Carcinoma2
ERBB2 S653C	(oncogenic)	Oncogenic	D	Supports Oncogenicity	2	submitted	EID11467 Variant found by RNA screening analysis in a UBC (urothelial bladder cancer) cell line (VM-CUBI). The variant is located in the transmembrane domain. RT112 cells infected with lentiviral vectors cont… (full text at CIViC) PMID 24971884 · de Martino et al., 2014 · Open in CIViC	civic
ERBB2 S653C	Lapatinib	Predictive	D	Supports Sensitivity Response	2	submitted	EID11468 Variant found by RNA screening analysis in a UBC (urothelial bladder cancer) cell line (VM-CUBI). The variant is located in the transmembrane domain. Regarding the response to lapatinib, after three d… (full text at CIViC) PMID 24971884 · de Martino et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.