ERBB2 I767M

CI-VAR-00002025Explore in graph →NP_004439.2:p.Ile767MetNM_004448.4:c.2301C>GCIViC 3664

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
ERBB2 I767M	(functional)	Functional	D	Supports Unaltered Function	3	submitted	EID10029 A series of HER2 (ERBB2) mutations (G309A, D769H, D769Y, V777L, P780ins, V824I, R678Q, R896C, del755-759, Y835F, I767M, and L755S) were functionally characterized and tested for sensitivity to lapatin… (full text at CIViC) PMID 23220880 · Bose et al., 2013 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.