ERBB2 G776V

CI-VAR-00001812Explore in graph →NP_004439.2:p.Gly776ValNM_004448.4:c.2327G>TClinVar 163410 CIViC 4470

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma1
ERBB2 L755P OR ERBB2 G776V OR ERBB2 G776delinsVC OR ERBB2 P780_Y781insGSP	Zongertinib	Predictive	A	Supports Sensitivity Response	4	accepted	EID12563 In the multicohort phase 1b Beamion LUNG-1 trial (NCT04886804) of zongertinib in HER2-mutant NSCLC, three cohorts were evaluated by mutation type and prior therapy. In cohort 1 (n = 75; HER2-TKD mutat… (full text at CIViC) PMID 40293180 · Heymach et al., 2025 · Open in CIViC	civic
Unmapped disease1unmapped disease
ERBB2 G776V	(functional)	Functional	D	Supports Gain Of Function	4	submitted	EID11295 The authors assess the functional significance of the 55 ERBB2 mutations listed in COSMIC as of October 2018. A novel cell line model developed by the authors (MANO) was used, which allows the integra…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.