Variant · Insertion
ERBB2 A775_G776insYVMA
CI-VAR-00000140Explore in graph →CIViC 4485
Curated evidence
Evidence by cancer (6 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22908275
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Lung Carcinoma1 | ||||||||
| ERBB2 A775_G776insYVMA | (oncogenic) | Oncogenic | D | Supports Oncogenicity | 4 | submitted | EID11494Cell proliferation analysis of NIH 3T3 cells harboring the A775_G776insYVMA insertion exhibit an increase of colony formation in soft agar compared with a wild-type ERBB2 and cells with ERBB2 D845A ki… (full text at CIViC) PMID 22908275 · Greulich et al., 2012 · Open in CIViC | civic |
| Lung Non-Small Cell Carcinoma4 | ||||||||
| ERBB2 A775_G776insYVMA | Afatinib | Predictive | B | Supports Sensitivity Response | 3 | submitted | EID7202Ten patients with heavily pretreated stage IV NSCLC had a documented A775_G776insYVMA ERBB2 mutation by local testing. Treatment with Afatinib showed median time-to-treatment failure (TTF) of 9.6 mont… (full text at CIViC) PMID 30096481 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available