EGFR L858Q

CI-VAR-00002435Explore in graph →NP_005219.2:p.Leu858GlnNM_005228.5:c.2573T>AClinVar 376281 CIViC 1473 rs121434568

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
EGFR L858Q	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID10040 EGFR mutations were selected (L861R, G724S, T725M, L858Q, E746K) using an ensemble machine learning approach to prioritize variants. CHO cells were transfected with EGFR-mutant or WT to functionally c… (full text at CIViC) PMID 24743239 · U et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.