DNMT3A R882H

CI-VAR-00003923Explore in graph →CIViC 1125 rs147001633

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Leukemia1
DNMT3A R882H	(oncogenic)	Oncogenic	D	Supports Oncogenicity	5	submitted	EID7232 The DNMT3A mutational hotspot at Arg882 (DNMT3A(R882H)) cooperates with NRAS mutation to transform hematopoietic stem/progenitor cells and induce acute leukemia development. Mechanistically, DNMT3A(R8… (full text at CIViC) PMID 27344947 · Lu et al., 2016 · Open in CIViC	civic
Unmapped disease2unmapped disease
DNMT3A R882H	(functional)	Functional	D	Supports Loss Of Function	4	submitted	EID13323 The DNMT3A R882H variant resulted had a statistically significant reduction in DNA methylation potential in NK-AML cells when compared to WT samples (p= 4.5 × 10-6), particularly when looking at focal… (full text at CIViC) PMID 24656771 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.