PIK3CA NM_006218.4(PIK3CA):c.325GAA[1] (p.Glu110del)

CI-VAR-00170182Explore in graph →p.Glu110delNM_006218.4:c.325GAA[1]ClinVar 995382 rs1724343994

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
995382	Likely pathogenic	reviewed by expert panel	3	PIK3CA related overgrowth syndrome; Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes; CLOVES syndrome; Angioosteohypertrophic syndrome; Rare venous malformation; PIK3CA-related disorder; Neoplasm; Embryonal rhabdomyosarcoma; Giant cell glioblastoma; Inborn genetic diseases	germline/somatic	14	Jun 06, 2025	clinvar