GRN NM_002087.4(GRN):c.328C>T (p.Arg110Ter)

CI-VAR-00018517Explore in graph →p.Arg110TerNM_002087.4:c.328C>TClinVar 98134 rs63750411

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
98134	Pathogenic	criteria provided, multiple submitters, no conflicts	2	GRN-related frontotemporal lobar degeneration with Tdp43 inclusions; Neuronal ceroid lipofuscinosis 11; Squamous cell carcinoma of the head and neck; Adult onset neurodegenerative disorder; GRN-related disorder	germline	11	Nov 23, 2023	clinvar