ASPM NM_018136.5(ASPM):c.5185C>T (p.Arg1729Trp)

CI-VAR-00018248Explore in graph →p.Arg1729TrpNM_018136.5:c.5185C>TClinVar 95889 rs41299623

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
95889	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Microcephaly 5, primary, autosomal recessive; ASPM-related disorder; Malignant tumor of esophagus; Adrenocortical carcinoma, hereditary; Ovarian serous cystadenocarcinoma; Acute myeloid leukemia; Sarcoma; Gastric cancer; Thymoma	germline	12	Jun 01, 2026	clinvar