Variant · Deletion
BRCA2 NM_000059.3(BRCA2):c.2808_2811del (p.Ala938Profs)
CI-VAR-00005866Explore in graph →p.Ala938ProfsNM_000059.3:c.2808_2811delClinVar 9322 rs80359351
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 9322 | Pathogenic | reviewed by expert panel | 3 | Breast-ovarian cancer, familial, susceptibility to, 2; Hereditary breast ovarian cancer syndrome; Hereditary cancer-predisposing syndrome; Breast neoplasm; Breast-ovarian cancer, familial, susceptibility to, 1; Familial cancer of breast; Breast and/or ovarian cancer; BRCA2-related disorder; Malignant tumor of breast; Uterine corpus cancer; Gastric cancer; Fanconi anemia complementation group D1; BRCA2-related cancer predisposition; Inherited ovarian cancer (without breast cancer); Inherited breast cancer and ovarian cancer | germline/somatic | 68 | Apr 22, 2016 | clinvar |