SHOC2 NM_007373.4(SHOC2):c.1541-7del

CI-VAR-00159278Explore in graph →NM_007373.4:c.1541-7delClinVar 928786 rs371544139

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
928786	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Noonan syndrome and Noonan-related syndrome; RASopathy; SHOC2-related disorder; Noonan syndrome-like disorder with loose anagen hair 1; Uterine corpus endometrial carcinoma; Gastric cancer; Nonpapillary renal cell carcinoma; Familial cancer of breast	germline	11	Feb 03, 2026	clinvar