PTEN NM_000314.8(PTEN):c.686C>G (p.Ser229Ter)

CI-VAR-00147328Explore in graph →p.Ser229TerNM_000314.8:c.686C>GClinVar 835735 rs1214965807

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
835735	Pathogenic	criteria provided, multiple submitters, no conflicts	2	PTEN hamartoma tumor syndrome; Hereditary cancer-predisposing syndrome; Autosomal dominant PTEN-related disorders	germline	5	Mar 01, 2026	clinvar