Variant · Snv
LAG3 NM_002286.6(LAG3):c.1468A>T (p.Ile490Phe)
CI-VAR-00127162Explore in graph →p.Ile490PheNM_002286.6:c.1468A>TClinVar 789318 rs139429051
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 789318 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Acute myeloid leukemia; Hepatocellular carcinoma; Lung cancer; Cervical cancer; Malignant lymphoma, large B-cell, diffuse; Sarcoma; Colon adenocarcinoma; Ovarian serous cystadenocarcinoma; Familial cancer of breast | germline | 3 | Jun 23, 2017 | clinvar |