Variant · Snv
LIG1 NM_000234.3(LIG1):c.2030G>T (p.Arg677Leu)
CI-VAR-00127276Explore in graph →p.Arg677LeuNM_000234.3:c.2030G>TClinVar 788029 rs3731008
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 788029 | Benign | criteria provided, multiple submitters, no conflicts | 2 | LIG1-related disorder; Colon adenocarcinoma; Sarcoma; Gastric cancer; Thymoma; Hepatocellular carcinoma; Uterine corpus endometrial carcinoma; Thyroid cancer, nonmedullary, 1; Cervical cancer | germline | 5 | Jan 14, 2026 | clinvar |