POLH NM_006502.3(POLH):c.447G>T (p.Gly149=)

CI-VAR-00127016Explore in graph →p.Gly149=NM_006502.3:c.447G>TClinVar 780623 rs2307464

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
780623	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Gastric cancer; Acute myeloid leukemia; Uterine carcinosarcoma; Nonpapillary renal cell carcinoma	germline	4	Feb 01, 2026	clinvar