Variant · Snv
SEC24D NM_014822.4(SEC24D):c.653C>G (p.Ala218Gly)
CI-VAR-00126351Explore in graph →p.Ala218GlyNM_014822.4:c.653C>GClinVar 771145 rs35392900
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 771145 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Cole-Carpenter syndrome 2; Malignant tumor of esophagus; Colon adenocarcinoma; Colorectal cancer; Nonpapillary renal cell carcinoma; Adrenocortical carcinoma, hereditary; Sarcoma; Gastric cancer; Lung cancer; Uterine corpus endometrial carcinoma; Thyroid cancer, nonmedullary, 1; Acute myeloid leukemia; Clear cell carcinoma of kidney; Thymoma; Melanoma; Hepatocellular carcinoma; Cervical cancer | germline | 8 | Feb 02, 2026 | clinvar |