LIG4 NM_206937.2(LIG4):c.2440C>T (p.Arg814Ter)

CI-VAR-00005714Explore in graph →p.Arg814TerNM_206937.2:c.2440C>TClinVar 7673 rs104894419

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
7673	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	DNA ligase IV deficiency; Multiple myeloma; Inborn genetic diseases; prenatal LIG4 syndrome with aqueductal stenosis; LIG4-related disorder	germline	15	Jan 16, 2026	clinvar