HCFC1 NM_005334.3(HCFC1):c.4263C>A (p.Pro1421=)

CI-VAR-00128480Explore in graph →p.Pro1421=NM_005334.3:c.4263C>AClinVar 728815 rs782566624

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
728815	Likely benign	criteria provided, single submitter	1	Methylmalonic acidemia with homocystinuria, type cblX; HCFC1-related disorder; Nonpapillary renal cell carcinoma	germline	3	Jan 31, 2026	clinvar