PTEN NM_000314.8(PTEN):c.955_958del (p.Leu318_Thr319insTer) — variant · CancerIndex

Variant · Other

PTEN NM_000314.8(PTEN):c.955_958del (p.Leu318_Thr319insTer)

CI-VAR-00014564Explore in graph →p.Leu318_Thr319insTerNM_000314.8:c.955_958delClinVar 71118 rs146650273

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
71118	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Cowden syndrome 1; Hereditary cancer-predisposing syndrome; PTEN hamartoma tumor syndrome; Ovarian neoplasm; Cowden syndrome; Breast carcinoma; Macrocephaly-autism syndrome; Neoplasm	germline/somatic	15	May 14, 2026	clinvar