SP110 NM_080424.4(SP110):c.1427A>G (p.Tyr476Cys)

CI-VAR-00114140Explore in graph →p.Tyr476CysNM_080424.4:c.1427A>GClinVar 661673 rs148808440

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
661673	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Hepatic veno-occlusive disease-immunodeficiency syndrome; Inborn genetic diseases; Clear cell carcinoma of kidney	germline	3	Jul 16, 2025	clinvar