POLG NM_002693.3(POLG):c.1550G>T (p.Gly517Val)

CI-VAR-00014446Explore in graph →p.Gly517ValNM_002693.3:c.1550G>TClinVar 65665 rs61752783

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
65665	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Mitochondrial disease; Idiopathic camptocormia; Progressive sclerosing poliodystrophy; POLG-related disorder; Tip-toe gait; Hereditary spastic paraplegia; Inborn genetic diseases; Thyroid cancer, nonmedullary, 1; Melanoma; Acute myeloid leukemia; Malignant tumor of esophagus; Clear cell carcinoma of kidney; Ovarian serous cystadenocarcinoma; Sarcoma; Uterine carcinosarcoma; Adrenocortical carcinoma, hereditary	germline	26	Jun 01, 2026	clinvar