FLNA NM_001110556.2(FLNA):c.4070G>A (p.Arg1357Gln)

CI-VAR-00121372Explore in graph →p.Arg1357GlnNM_001110556.2:c.4070G>AClinVar 641236 rs782490288

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
641236	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Heterotopia, periventricular, X-linked dominant; Oto-palato-digital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia; Familial thoracic aortic aneurysm and aortic dissection; Thyroid cancer, nonmedullary, 1	germline	5	Feb 25, 2026	clinvar