Variant · Snv
TP53 NM_000546.6(TP53):c.919+1G>A
CI-VAR-00113470Explore in graph →NM_000546.6:c.919+1G>AClinVar 633606 rs1131691039
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 633606 | Pathogenic | reviewed by expert panel | 3 | Li-Fraumeni syndrome 1; Li-Fraumeni syndrome; Hereditary cancer-predisposing syndrome; Adrenocortical carcinoma, hereditary; TP53-related disorder; Malignant tumor of esophagus; Familial cancer of breast; Nonpapillary renal cell carcinoma; Ovarian serous cystadenocarcinoma; B-cell chronic lymphocytic leukemia | germline/somatic | 12 | Aug 05, 2024 | clinvar |