LRP5 NM_002335.4(LRP5):c.4488+2T>G

CI-VAR-00005583Explore in graph →NM_002335.4:c.4488+2T>GClinVar 6287 rs80358322

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
6287	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Exudative vitreoretinopathy 4, autosomal dominant; Familial exudative vitreoretinopathy; Inborn genetic diseases; Exudative vitreoretinopathy 4; Retinal dystrophy; Osteoporosis with pseudoglioma; Ovarian serous cystadenocarcinoma; LRP5-related disorder	germline	11	Jan 15, 2026	clinvar