CACNA1D NM_000720.4(CACNA1D):c.1480T>C (p.Cys494Arg)

CI-VAR-00109713Explore in graph →p.Cys494ArgNM_000720.4:c.1480T>CClinVar 592974 rs201775251

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
592974	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Sinoatrial node dysfunction and deafness; Aldosterone-producing adenoma with seizures and neurological abnormalities; Inborn genetic diseases; Congenital anomaly of kidney and urinary tract	germline	5	Jan 30, 2026	clinvar