Variant · Snv
SIK1 NM_173354.5(SIK1):c.948C>T (p.Gly316=)
CI-VAR-00109454Explore in graph →p.Gly316=NM_173354.5:c.948C>TClinVar 586589 rs17004546
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 586589 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Developmental and epileptic encephalopathy, 30; Inborn genetic diseases; Acute myeloid leukemia; Adrenocortical carcinoma, hereditary; Cervical cancer; Uveal melanoma; Uterine carcinosarcoma; Uterine corpus endometrial carcinoma; Colon adenocarcinoma; Thymoma | germline | 6 | Feb 04, 2026 | clinvar |