Variant · Snv
MET NM_000245.4(MET):c.4082G>A (p.Cys1361Tyr)
CI-VAR-00105512Explore in graph →p.Cys1361TyrNM_000245.4:c.4082G>AClinVar 582596 rs766190061
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 582596 | Uncertain significance | criteria provided, multiple submitters, no conflicts | 2 | Renal cell carcinoma; Hereditary cancer-predisposing syndrome; Osteofibrous dysplasia; Papillary renal cell carcinoma type 1; Autosomal recessive nonsyndromic hearing loss 97; Hepatocellular carcinoma; Arthrogryposis, distal, IIa 11 | germline | 3 | Dec 15, 2025 | clinvar |