SPG11 NM_025137.4(SPG11):c.2003A>G (p.Tyr668Cys)

CI-VAR-00106679Explore in graph →p.Tyr668CysNM_025137.4:c.2003A>GClinVar 566380 rs764762491

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
566380	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Hereditary spastic paraplegia 11; Amyotrophic lateral sclerosis type 5; Charcot-Marie-Tooth disease axonal type 2X; Inborn genetic diseases; Colorectal cancer	germline	9	Jan 01, 2026	clinvar