LZTR1 NM_006767.4(LZTR1):c.848G>A (p.Arg283Gln)

CI-VAR-00102695Explore in graph →p.Arg283GlnNM_006767.4:c.848G>AClinVar 561716 rs1223430276

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
561716	Likely pathogenic	reviewed by expert panel	3	Noonan syndrome 10; Noonan syndrome and Noonan-related syndrome; RASopathy; Noonan syndrome 1; Male infertility with azoospermia or oligozoospermia due to single gene mutation; Hereditary cancer-predisposing syndrome; Cardiovascular phenotype; LZTR1-related disorder; LZTR1-related schwannomatosis; Neoplasm	germline/somatic	18	Dec 03, 2024	clinvar