FANCM NM_020937.4(FANCM):c.2586_2589del (p.Lys863fs)

CI-VAR-00100948Explore in graph →p.Lys863fsNM_020937.4:c.2586_2589delClinVar 545911 rs768006618

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
545911	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Fanconi anemia; Spermatogenic failure 28; Hereditary cancer-predisposing syndrome; FANCM-related disorder; Premature ovarian failure 15	germline	11	Mar 27, 2026	clinvar