TP53 NM_000546.6(TP53):c.993+1G>A

CI-VAR-00099955Explore in graph →NM_000546.6:c.993+1G>AClinVar 528261 rs11575997

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
528261	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Li-Fraumeni syndrome; Ovarian neoplasm; Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome 1; Neoplasm; Squamous cell carcinoma of the head and neck; Squamous cell lung carcinoma; Ovarian serous cystadenocarcinoma; Malignant tumor of urinary bladder; Pancreatic adenocarcinoma; Colon adenocarcinoma; Familial cancer of breast; TP53-related disorder	germline/somatic	10	Sep 07, 2025	clinvar