Variant · Deletion

SDHB NM_003000.3(SDHB):c.201-4429_287-934del

CI-VAR-00094417Explore in graph →NM_003000.3:c.201-4429_287-934delClinVar 523118

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
523118	Pathogenic	no assertion criteria provided	0	Pheochromocytoma/paraganglioma syndrome 4	germline	1	Jan 11, 2006	clinvar

Nomenclature

Record

Gene: SDHB
Type: Deletion
HGVS c.: NM_003000.3:c.201-4429_287-934del
Assembly: GRCh38
Position: chr1:17029669-17037574
Ref / Alt: TGTCTTGGTCATCTTAAGGTTGAAGTGACCTGGATACAGATTATTAAGAGATAGCTCTTCTTCTTTTTTTTTCTTGGCTGAGTCTTGCTGTGTCACCCAGGCTGAAGTACAGTGGTGGAGTCATAGCTCACTGTAGCTCACTTTAGCCTCAAACTTCTGGGCTCAAGCGATCCTCCCACCACAGCCTCCTGAGTAGTTGGGACTACAGGCACATGCCGCCATGTGCGGCGAATTCAAAAAAATTCTTTGTAGGTTGGGTGAAGTGGCTCACACCTGGAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGTTTGGCCAACATGGTAACCCCCTGTCTCTACTAAAAATATAAGTCGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGGTGAGGCGGGAGAATCATTTGAACTGAGGAGGAGAAGGTTGCAGTGAGCAGAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGATTCCATCTCAAAAAAAAGAAAAAAATAATTGTTTTTTGTAGAGCAGGTGTCTCACTATATTGCCCAGGCTGGTCTCTAACTCACGGCCTCAAGTAATCCTTCTGCCTTTGCCTCCCACTGTGTTGGGATTACAGGCCTGAGCCACTACACTTGACAGAGGTAAGGCTTCTTCTATTGTCTTCATAAAATACGCAGCATAGTACCCTGGGGCTATGAAATCCACAAAAGCTGACTCAGCATGGACTTTCCAAAGAGGAGAAGAATGAACTAATATGAAACTGAGGCAAAGCAAAGCAAACTAAACAAAAAACGTGCTGACCCAGGACCCCGACATGAGAATTTTCTTAGCCTGGACCTACTTCCTGTATATGGAAATTTCCTGGGTGTTTTGGAATTTAAAAATGATTATGTACTCTAAACCTCTAGTGCCAGTCCTCTGAAGCTGTTTTTTGAAGATCATTAGGTCAGAGAAACCTGATTGCTTGAGAAAGTTGCACTGGTTATCATCTTTTTTTTTTTTTAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTTACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGACGCCCGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTTACCACGTTGGTCAGGCTGGTCTCGAACTCTGACCTTGTGATCTGCCCGCCTCGGCCTCTGAATGCCTGGCCTCACCTTTTTTTTTTTTTTTTTTAATGGAAAGGGAGTCTATGTTTCCCAGGCTGGTCTTAAACTCCTAGCCTCAAGCTAGCCTACCACCTAGACCTCCCAAAGTACTGGGATCACAGGCGTGAGCCACTGCGCCCAGTCGGTTATCACTTTCATAAGACTAGAAAAGACAGTAAGACTCTCCTTCTCCTGTAAATCTTAGAAAGAGTGTAAGGGAACCCAAAGATGTGTCTTAAGCAAATACTCCTAGAGTTCCCCAAGAGACTGGATATTATCAATACATTTATGTATACCTGGCATCCAACTAGAGCAGTTTGCTTTTACAAGAAATGGCATAAAAATTAAAAAAATAAATCCAATGAACTTTCTCTCAAAAAGGCTCCCTGGGAATTCTCTTACAAGATGGGAATTAAAAAAAAAATAAGAAAAACAAGATGGGAATAAAAAGGAGTAGCAATTGATACAATTCTGCTTTATTTTTTTTAGTCCAGATGGGTCACACCTTATGTTCTTGGTTCTGAAAGAGTCCTACAGGGAAAGGTTACTGAAAAGCATCTACCTTTCCTGTGTTGCCAGGACTTAATGGGGAAGGCTGCTGTTTAACTGCCGCAGAATGTTCCCTGAACAGCAGGACTCAGCCGAACTATCATAATATCCATCAGCATTTGCAACGCTAAATAAGATTAGCTGAATCAAAACAGATGTCTTAAAAGACTTGAAATGCTTGAAATGTACAGCTGAACAGATAAAAAGCCATGGGCCGGTATCAATACTGGCTTTTCCTTTTTTTTTAAGGTTTTCTTAGAAAAAAGCTCAGTGTCCTCACAGAATCAAGCTACTCTCTGCTTTTGTTTTATCCCAGGTGTTCCAAGCCAAGTCAGTGCCTGAGAGAGCAGATCTGGAGTCTGGAGTCTGACAGCTTTGGCTGACTCCCGGCTCTCAAGTCACTCTCTATGTGTCCTTGTGGAAGTCCATTACCCTCTCTGGGCCTCACCTTTAAATTGAAGGTAGATAATAAGCACAGTCATCTACCTCATGTCCAGTGCACAGAACAGAGCCGGGCACACAGTCTGGCTCCACGGACATCAGGCCAGTCGGTCTTCACTGCACCCTGTGCAATTTTTGCTATACCTGAGAACCACCTGAATCAACTTTCTTTAAAGTATCTCTTGGGTTTTCTTTAACTTGTTTTGCTTAAATTCACATTAAAAAACCACTTATATCCCTATTATACCATCATTAGTAATTATATTTTTCTTTTTTTTTTTTTTGAGACTGTCTCGCTCTATTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAAACTCCACCTCCCGGGTTCCTGCCTCAGCCTCCCGAGTAGCCAGGATTACAGGCGTCCGCTATCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGCCAGGTTGATCTCGAACTCCTGACGCCAGCTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCCGGCAGTAATTATATTTTTCTAATACAGAAAATGAATACATTGCTATTCATGTAGAAAATGTTAGTCTGCACACTGCCTCAAATGGGCTCATGTGGCACCAGCAGCACAAGTAACCACATGCTGAGGGAGACACTGTACCAGCCAATCCAGAACACAGCTACCAAGGACATGTCATGCTGGGAGCTGAGGGAGACTCACACATCTCCCCTGCTGGACAAGCATAAGTGCCAGACAGAAACTCTCCACTGCTCCCTTAATAAAAGAGCTCAGCAGCATGGAAGGTGCCAGCCAGCAGGTCCTAGCTAGGCCTTGAAGCGTGGAGCAGCTCACAGGGACCGCCAGATGCAGTAACCACAGGATAGAATGCTCCTGAAGGAAAGTAAACTCAGAAACCAGAACTTGCACCATGGTTAGAATTTTGGATGCATTTACCCAAGAAAAGGAATTAGGTTGCACAGCAAGTTCACCCAGCAGAGAGCTGCAGCTGTTTTCCAGATGTCTCTATCAGCTTTGGCCAGCCCAAGCCTCTTTGGAAGACCACAAGTATCTGGAGCCCAACAGGAATGAAATGCTCACCTTCTCTGCATGATCTTCGGAAGGTCAAAGTAGAGTCAACTTCATTCTTAATCTTGATTAAAGCATCCAATACCATGGGGCCACATCTAACAAAGAAAAATATCCAGTGGTATTTATGTAACGTTCAACCTCCCTACACTTTATCATAATATAATCGGAGACACCTGGATGTATTAGCTTATCCATTTGGTCTTCTCAGGTCACCTTCGGAATTTGTTCTGTAGTTTTGTTTTTGCAGATTCTTACATTTTAAGTACTGCACAGTTCTATTTTGATGATCACAGTGCAAACACATTTCTAGGAAATGGAAAGCTAAAGTAGTAGTAGACAAGTATGACACAACTTCCATACAGTGGCCGAGTTTTTGTTTTTTACTTCTGAAGCTCCCTGCAAAGTTTTTCCAAATAATTTATTTCAAATTTTAGTTTGATTTTTAGGATGTAGACAATAGTTTTAAATAGTAATTAATAATACATAACCATAAGAGAAGACATAGTACAGAGAATAAAAGACACCCAATCACTCACAGTCCCCCAGTCAAATCACTGTGAGCCTCCTAGAACATACAAGGGCAGTGACATGGTACTAAGCGGAGCATCCCTGGGCGTGGGACCTGGAGTGCCGGCCTGGCAGCCAAGAGACTGGTCTGCACCATGGCTGAGCCACTTACCAGCTTGCAGGCAAATGATTTAATTTCTGCCTAGGCATTTAATCCACTGAGTGCAGAGAGCAGCACCTGCATCCCACAGGATTGCTGGAGGTGAGTTAATACACACGAGATCTTTACAGCAGCATCTGACATATAAATCATAGTTTAACTATAATAATCATCATGCAGAAACTGTGATTCTACGGAAATTACTCTCTGAACCTCAGTTTATCTGTAGAGTTAATATTTACACCACAGGGTTACTGTGAAAATTACATAAAAATATGTAATTTTTCATAGTACCTGGCATACAGTAAGTGCTCCACAAATCTATTTTCTGGTTGCCACCCTGCCCCCATTCCACTCACTAATTTTCTATGCATGAGATTAAAAATATACTTAAAAATACGTCATTTCCTTTAGTACTATCTGTATTTCATTTTTTTTCTTTTTTTTCTTGAGACGGGGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGCACGATCTCAGATCTGTAACCTCCGCATCCCAGCCTCAAGAGATCCTCCTGCCTCAGCCCCCCAGTAGCTGGGACTACAGGTATGTGCCACCACATCCAGCTTAATTTTTGTATTTTTTTGTAGAGGTGGGATTTCGCCATGTTGCCCAGGCTGGTCTCTAACTCCTGGACTCAAGTGATCCTCCTGCCTTGGATTCTCAAAGTGTTGGGATTATGGGTGTGAGGCAATGGTGCGATCTCGGCTCACTGCAACCTCTACCTTCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCATGCCACCACACCCGGCAAATTTTTGTATTTTTAGTAGAGATAGGTTTTCCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTTCCCAAATGCTGGGATTACAGGTGTGAGCGACTGCGTCTGGCCCATTATCTGTATTTGTATCAGCACTATGTAGACGTCCTTTCTGCTGGACCTCTGCTAACACTGGGAATTGGAAGCTTTAAAAACCTTTGCTATTCTGATACTGGAGAAGTGTTATTGTTTTCAGTGTTTTAAATCGAGACTTTTGAATACTACATAGGTTGAATGTTTGTCATAAATTTACTAATTTTTCTTTATTTCCCAATTATTTATTGAACATTTACTCTGCCAGGTTCTGTTCTAGATGCTGGGGATGTAGCAGAGAATAAAAGAGACGAATACCACCTGCCCGCACAAAGCTCTGTTCCAGAGGACTCATTCTAGAGACTCAGTCTGTCCACATTCTTTGCCTCTGTTTACCAGGGTCTTGGAAATTCTTTTTCATGATCTGAGGCTCTTATATATTATATCTGTTGCCATTTCTGCTTCCTCCCTCACTGCCAATAGTAATGTGCTATTTGACTTCTAATTTTGGTAACAGAATTTTAAACATACATGAGTTAAATGTTTACATTAATAAAGGTGGCTATTCTTTCTTTTATAACATTATCTATCACTTTTAAGCCTAAACAGACCACTGCCCTTCCTGAGGTCTGATAAATACTTTACATTTTTTTCTACTTAAAAAAAATTTTAAGTTACTCCCCTAAAACTGCAAAAACTGTATCAGTTGTCCCAAATCACTGACTAAATCCTCTTTTGCTTCTTATTTGTAATACCTTTCTCCCATATTTAATACTGGGAACTTAGATAAAATTGAGTCTGTTTTGTTGCTACATTTTTATTCTAATGATCTGCCTGTTCTTGTCCTAGCATATTTTAAATGACAACAACATCTTTGTTTTTTTTACATTACAAAGGCTAATATTTGCAGCCTATAAAAATTTCAAATTGGCCAGGTGGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCACTTTGGGAGGCCTTGGCGGGTGGATCATGAGGTCAGGAGATTGAGACCATCCTGGCTAACGTGGTGAAACCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTTGCACGTGCCTGTAGTCCCAATTACTTGGGAGGCTGAGGCAGGAAAATTGCTTGAACCCCAGAGGCGGAGGTTGCAGTGAGCCGAGACCGCACCACTGCACTCCAGCCTGGGAGACAGAGCGAGACTGTCTCAAAAAAATAAATAAATAAATAGATAAATAAATAAATAAATTCAAATCAAAGGTAAAAAGTAATCCTGCAGATCATACTGGGACAGAGAAAAATATTAAAAAGTCAAAGTCCTCTCTTTAAGCTGTTTCATGCTAAATTTCCTAATAGGTAGGGCTCATTAAAGAGTACAACATAAATTTTCTCAGATTTTACATAGATACCAAAATTGTTTGATATTCTGGGTCCCTTGCATTTCTATAAGATTTTTAGAATCAACTTGTCAACTTCTGCAGAAAAGGCAGGTGGGATTTTGATGGGGATTGCAATGAATCTGGAAATCAATTTGGAGACCACTGCCTCCTTAACAACATTAAGTCTTCCAACCCACAAACAGGGCATGTCTTTCCATTTATTTATGTCTTCTTAAATTTCTTTCAACAATGTTTTACAGTTTTTCAGCATATAAGTCTTTTACTTATTTGATTTTTGAGACAGGATCTCACTCTGTCGCCCAGGCTGGATGGAGTGCAGTGTTGTGATCACAGCTCACTGCAGGTTTGACCTCCCAGGCTCAAGTGATTCTCCCACCTCAGCCTCCAAGTAGCTGGGACTATAGGCACAGGAAGGTCATCAAGCCCAGCTAACTTTTTTTGTAGAGATGGGGTTTTGTCTTATTGCCCATATAATTTGTTCCTAAGAATTTCTTTTTTGATGCTGTTATATGGAAAATAGTTTTTAAATTTCATTTTAGGATTGTTCATTGCTAGTGTATAGAAATCCAATTTTTGTTTTTTTAACAGTACTTACAGGCTTTTTTCTAGGTAAGCAGGGTTTTACATATATAAATATAAATATTTATATAAATATGAATATATAAATATAAATATTTATATAAATATGAATATATAAATATAAATATTTATATAAATATGAATATATAAATATAAATACATATATAAATATATATGTATACACACACACACACACATTTTTTCTGTAGAGACTAAGTCTTGCTATTGTTGCCCAGGCTGGTCTCAAAACTCCTGGCCTCAAGCAATCCTCCTGCCTTGGCCTCACAAAGAAAGTGCTAGTATTACAAGTGTGAGCCACCATGCCTAGCCTAGAAAAATACATTTATCTGCTAATATCTGCTACACGCCAGTATTTTCAGAAAAAGAATTATGCTGTTGTGAAAATGAAAGAATATAGCTATTTTTTGTGTGTGTATACATAGCTACAAAGTAGGGTTTCAGAGTCGGATTAGAAGGAAATAGAACTATAATTAAAACATGGTACAATATAAAATGAAGACTGACAGACATAGGTTGAAATAAACATGGACAAATTATGCATAATAAAAAACTAAACTACATTTGATTTCTGTATACCAGTTTTGTGTCCTCCAACCTTGCTGAATTTGTTCATTAGTTCTAATAGTTCCTAGGGGGCAATGTCTTATATTTTCTTTTCTTTTTTTTTTTTGAGACAGCGTCTCCCTCTGTTGCCCAGGCTGGAGTGTAGGGCATGGAATCATGGCTCACTGCAGCCTCGACCTCCTGGGTTCAAGTGATCCTCCCACCCCACCCTCCCAAGTAGCTCGGACTACAGGAGTGTGCCACCACACCTGGCAAATTTTTTGAGACACAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCTGCCACCTAGGTTCAAGCAATTCTTGTGCCTTA 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