HNF1B NM_000458.4(HNF1B):c.1657C>A (p.Pro553Thr)

CI-VAR-00092987Explore in graph →p.Pro553ThrNM_000458.4:c.1657C>AClinVar 499802 rs147798914

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
499802	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Renal cysts and diabetes syndrome; Type 2 diabetes mellitus; Nonpapillary renal cell carcinoma; HNF1B-related disorder; Maturity-onset diabetes of the young	germline	9	Mar 23, 2026	clinvar