SMARCA4 NM_001387283.1(SMARCA4):c.4255C>T (p.Arg1419Cys)

CI-VAR-00089098Explore in graph →p.Arg1419CysNM_001387283.1:c.4255C>TClinVar 480587 rs1056234449

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
480587	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Rhabdoid tumor predisposition syndrome 2; Intellectual disability, autosomal dominant 16; Hereditary cancer-predisposing syndrome; Medulloblastoma non-WNT/non-SHH group 3	germline/somatic	7	Jan 26, 2026	clinvar