Variant · Snv
NPRL3 NM_001077350.3(NPRL3):c.180C>T (p.Gly60=)
CI-VAR-00077941Explore in graph →p.Gly60=NM_001077350.3:c.180C>TClinVar 476222 rs75187722
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 476222 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Epilepsy, familial focal, with variable foci 3; NPRL3-related disorder; Ovarian serous cystadenocarcinoma; Thymoma; Thyroid cancer, nonmedullary, 1; Acute myeloid leukemia; Malignant tumor of esophagus; Uterine corpus endometrial carcinoma; Sarcoma; Nonpapillary renal cell carcinoma; Clear cell carcinoma of kidney; Gastric cancer; Lung cancer; Adrenocortical carcinoma, hereditary; Cervical cancer | germline | 6 | Feb 03, 2026 | clinvar |