Variant · Snv
VPS45 NM_007259.5(VPS45):c.1032A>G (p.Glu344=)
CI-VAR-00072108Explore in graph →p.Glu344=NM_007259.5:c.1032A>GClinVar 474243 rs74127419
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 474243 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Congenital neutropenia-myelofibrosis-nephromegaly syndrome; Uterine corpus endometrial carcinoma; Colon adenocarcinoma; Squamous cell carcinoma of the head and neck; Gastric cancer; Lung cancer; Sarcoma; Ovarian serous cystadenocarcinoma; Cervical cancer; Thymoma; Melanoma; Acute myeloid leukemia; Hepatocellular carcinoma; Malignant tumor of esophagus | germline | 8 | Feb 03, 2026 | clinvar |