Variant · Snv
PIK3CD NM_005026.5(PIK3CD):c.1953C>T (p.Leu651=)
CI-VAR-00072392Explore in graph →p.Leu651=NM_005026.5:c.1953C>TClinVar 474025 rs140468930
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 474025 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Immunodeficiency 14; Clear cell carcinoma of kidney; Familial pancreatic carcinoma; Sarcoma; Ovarian serous cystadenocarcinoma; Malignant tumor of esophagus; Familial cancer of breast; Malignant lymphoma, large B-cell, diffuse; Gastric cancer; Cervical cancer; Ovarian cancer; Thymoma; Thyroid cancer, nonmedullary, 1; Melanoma; Hepatocellular carcinoma | germline | 6 | Feb 04, 2026 | clinvar |