CHCHD10 NM_213720.3(CHCHD10):c.378C>T (p.Ser126=)

CI-VAR-00080972Explore in graph →p.Ser126=NM_213720.3:c.378C>TClinVar 473427 rs199579266

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
473427	Likely benign	criteria provided, multiple submitters, no conflicts	2	Lower motor neuron syndrome with late-adult onset; Autosomal dominant mitochondrial myopathy with exercise intolerance; Frontotemporal dementia and/or amyotrophic lateral sclerosis 2; Inborn genetic diseases; CHCHD10-related disorder; Clear cell carcinoma of kidney	germline	6	Oct 08, 2025	clinvar