TTN NM_001267550.2(TTN):c.69676A>G (p.Ser23226Gly)

CI-VAR-00008736Explore in graph →p.Ser23226GlyNM_001267550.2:c.69676A>GClinVar 47275 rs72646885

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
47275	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Autosomal recessive limb-girdle muscular dystrophy type 2J; Dilated cardiomyopathy 1G; Cardiovascular phenotype; Cardiomyopathy; Ventricular tachycardia; Familial dilated cardiomyopathy and peripheral neuropathy; Hypertrophic cardiomyopathy; Myopathy, myofibrillar, 9, with early respiratory failure; Tibial muscular dystrophy; Early-onset myopathy with fatal cardiomyopathy; TTN-related disorder; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Clear cell carcinoma of kidney; Familial pancreatic carcinoma; Sarcoma; Lymphoma; Malignant tumor of esophagus; Lung cancer; Ovarian cancer; Ovarian serous cystadenocarcinoma; Uterine carcinosarcoma; Thyroid cancer, nonmedullary, 1; Melanoma; Colon adenocarcinoma; Gastric cancer; Nonpapillary renal cell carcinoma; Cervical cancer	germline	25	Jun 01, 2026	clinvar