TTN NM_001267550.2(TTN):c.20861C>T (p.Ala6954Val)

CI-VAR-00008722Explore in graph →p.Ala6954ValNM_001267550.2:c.20861C>TClinVar 46677 rs17355446

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
46677	Benign	criteria provided, multiple submitters, no conflicts	2	Cardiovascular phenotype; Tibial muscular dystrophy; Myopathy, myofibrillar, 9, with early respiratory failure; Early-onset myopathy with fatal cardiomyopathy; Dilated cardiomyopathy 1G; Autosomal recessive limb-girdle muscular dystrophy type 2J; Thymoma; Acute myeloid leukemia; Nonpapillary renal cell carcinoma; Cervical cancer; Familial pancreatic carcinoma; Ovarian serous cystadenocarcinoma; Uterine corpus endometrial carcinoma; Sarcoma; Uterine carcinosarcoma	germline	17	Feb 04, 2026	clinvar