Variant · Snv
KIT NM_000222.3(KIT):c.1670G>A (p.Trp557Ter)
CI-VAR-00073722Explore in graph →p.Trp557TerNM_000222.3:c.1670G>AClinVar 458885 rs1057520032
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 458885 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Gastrointestinal stromal tumor; B Lymphoblastic Leukemia/Lymphoma with t(v; 11q23.3); KMT2A Rearranged; Hereditary cancer-predisposing syndrome | germline | 3 | Mar 31, 2026 | clinvar |