RYR1 NM_000540.3(RYR1):c.9703A>C (p.Ser3235Arg)

CI-VAR-00072044Explore in graph →p.Ser3235ArgNM_000540.3:c.9703A>CClinVar 450330 rs747488155

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
450330	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	RYR1-related disorder; Malignant hyperthermia, susceptibility to, 1; Central core myopathy; Inborn genetic diseases	germline	6	Jun 23, 2025	clinvar