ABCB6 NM_005689.4(ABCB6):c.1562C>G (p.Thr521Ser)

CI-VAR-00071673Explore in graph →p.Thr521SerNM_005689.4:c.1562C>GClinVar 445477 rs149363094

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
445477	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Protoporphyria, erythropoietic, 1; Acute intermittent porphyria; Variegate porphyria; Hereditary coproporphyria; Uveal melanoma; Melanoma; Adrenocortical carcinoma, hereditary; Colorectal cancer; Ovarian serous cystadenocarcinoma; Uterine carcinosarcoma; Thyroid cancer, nonmedullary, 1; Clear cell carcinoma of kidney; Acute myeloid leukemia; Lung cancer	germline	13	Jan 13, 2026	clinvar