TP53 NM_000546.6(TP53):c.920-2A>G

CI-VAR-00008533Explore in graph →NM_000546.6:c.920-2A>GClinVar 43595 rs397516439

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
43595	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Li-Fraumeni syndrome; Hereditary cancer-predisposing syndrome; Ovarian neoplasm; Breast and/or ovarian cancer; Li-Fraumeni syndrome 1; Familial cancer of breast; Squamous cell carcinoma of the head and neck; Ovarian serous cystadenocarcinoma; Lung cancer; Neoplasm; Squamous cell lung carcinoma; Hepatocellular carcinoma	germline/somatic	13	Mar 10, 2026	clinvar