Variant · Snv
CFTR NM_000492.4(CFTR):c.1584G>A (p.Glu528=)
CI-VAR-00008526Explore in graph →p.Glu528=NM_000492.4:c.1584G>AClinVar 43576 rs1800095
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 43576 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Hereditary pancreatitis; Cystic fibrosis; Pancreatitis; CFTR-related disorder; Congenital bilateral aplasia of vas deferens from CFTR mutation; Bronchiectasis with or without elevated sweat chloride 1; Uterine corpus endometrial carcinoma; Familial pancreatic carcinoma; Colon adenocarcinoma; Thymoma; Thyroid cancer, nonmedullary, 1; Cholangiocarcinoma; Malignant tumor of esophagus; Nonpapillary renal cell carcinoma; Gastric cancer; Ovarian serous cystadenocarcinoma; Lung cancer; Colorectal cancer; Lymphoma; Adrenocortical carcinoma, hereditary; Cervical cancer | germline | 24 | Jun 01, 2026 | clinvar |