MYO7A NM_000260.4(MYO7A):c.3476G>T (p.Gly1159Val)

CI-VAR-00008520Explore in graph →p.Gly1159ValNM_000260.4:c.3476G>TClinVar 43206 rs199897298

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
43206	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Rare genetic deafness; Autosomal recessive nonsyndromic hearing loss 2; Retinal dystrophy; Hearing loss; Usher syndrome type 1B; Usher syndrome type 1; Autosomal dominant nonsyndromic hearing loss 11; Hereditary breast ovarian cancer syndrome; MYO7A-related disorder; Monogenic hearing loss	germline	18	Sep 09, 2026	clinvar