Variant · Snv
MYH7 NM_000257.4(MYH7):c.1062C>T (p.Gly354=)
CI-VAR-00008519Explore in graph →p.Gly354=NM_000257.4:c.1062C>TClinVar 42819 rs735712
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 42819 | Benign | reviewed by expert panel | 3 | Cardiovascular phenotype; Hypertrophic cardiomyopathy; MYH7-related skeletal myopathy; Cardiomyopathy; Hypertrophic cardiomyopathy 1; Myosin storage myopathy; Nonpapillary renal cell carcinoma; Adrenocortical carcinoma, hereditary; Colorectal cancer; Cholangiocarcinoma; Uterine carcinosarcoma | germline | 20 | Nov 11, 2025 | clinvar |