RB1 NM_000321.3(RB1):c.411A>T (p.Glu137Asp)

CI-VAR-00008285Explore in graph →p.Glu137AspNM_000321.3:c.411A>TClinVar 41684 rs3092902

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
41684	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Hereditary cancer-predisposing syndrome; Retinoblastoma; RB1-related disorder; Malignant tumor of urinary bladder; Small cell lung carcinoma; Bone osteosarcoma	germline	16	Jun 18, 2026	clinvar