SPAG1 NM_003114.5(SPAG1):c.1542G>A (p.Leu514=)

CI-VAR-00061208Explore in graph →p.Leu514=NM_003114.5:c.1542G>AClinVar 416525 rs117747863

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
416525	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Primary ciliary dyskinesia 28; Primary ciliary dyskinesia; Lung cancer; Familial cancer of breast; Clear cell carcinoma of kidney; Colorectal cancer; Gastric cancer; Thyroid cancer, nonmedullary, 1; Melanoma; Hepatocellular carcinoma; Acute myeloid leukemia; Malignant tumor of esophagus	germline	6	Feb 02, 2026	clinvar