CDKN2A NM_000077.5(CDKN2A):c.442G>A (p.Ala148Thr)

CI-VAR-00008189Explore in graph →p.Ala148ThrNM_000077.5:c.442G>AClinVar 41580 rs3731249

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
41580	Benign	criteria provided, multiple submitters, no conflicts	2	Hereditary cancer-predisposing syndrome; Melanoma-pancreatic cancer syndrome; Familial melanoma; Melanoma, cutaneous malignant, susceptibility to, 2; Li-Fraumeni syndrome; Familial pancreatic carcinoma	germline	25	Feb 04, 2026	clinvar